Saturday, June 02, 2007

Another Look at Soden et al.

I covered Soden et al. a few days ago.
After carefuly thinking about the study I have some further comments and descriptions.

Participants

-15 chidlren with AD were included and 4 typically developing children.
-Aged 3-7, mean age of 4.62
-Past chelation experience was not permitted
-Only children diagnosed with Autistic Disorder were included
-Diagnosis was confirmed using standardized assesments and direct observation.

Study Limitations

-Only 24 hours were used, some have theroized that 72 might be needed for various reasons in chidlren with autism
-No treatment integrity data were taken on parent adherence to the procedure.
-Study can not rule out chelation as a useful treatment for autism, for reasons other than removing heavy metals

Statistics

-Confidence interval was 0-22%, so a larger sample of autistic children was unlikely to change the result
-Statistical analysis was appropriate and adequate, however a MANOVA statistical design may have provided additional data.

Other

This study was completely funded from a Bridege Grant from
Cure Autism Now


2 Comments:

Anonymous passionlessDrone said...

Hi Interverbal -

Another potential issue with this study is the dosage and route of transmission.

By way of example, here is a pub med study showing that dosages around 1000 mg were significantly more efficient at removing lead than dosages of 750 or 350.

Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.

I know several children that are getting one time doses (once a day) in the 200 or 250 mg range, that is, one dose at 200mg during the day. Also, these are in the form of suppositories, not oral administration. I'm told that suppositories allow for greater absorption than oral, but I cannot find anything on the absorption rate of suppositories.

I did find one article indicating in animal expirements only between 20% and 30% of orally administered DMSA was absorbed.

Full Link (no pubmed)

Do you know what the route for entry was in the study referenced?

Take care!

-pD

(If this double posted, delete one. Very slow response from blogger.com this morning!)

6:15 AM  
Anonymous passionlessDrone said...

Hi Interverbal -

Another reason to use suppository transmission as opposed to oral is that the oral DMSA has a tendency to disrupt the baterial balance of the gut; something which many parents of autistic children have spent considerable time and effort to try to correct.


-pD

6:28 AM  

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